The molecular basis of antiphospholipid syndrome.

P-75: The Association of Antiphospholipid Syndrome and Recurrent Miscarriages

a:4:{s:10:"Background";s:364:"Antiphospholipid syndrome is a coagulation disorder that causes recurrent miscarriages and fetal deaths. In the present review we summarize current knowledge about Antiphospholipid syndrome that associated with recurrent miscarriages. In addition, on the basis of these comprehensive data, possible pathophysiologic mechanisms of this disorder are discussed.";s:19:"M...

Revisiting Beta 2 Glycoprotein I, the Major Autoantigen in the Antiphospholipid Syndrome

Beta 2 glycoprotein I (β2GPI) is a single chain 50 kDa highly glycosylated glycoprotein at an approximate concentration of 4 μM in cells. The abundance of this protein in plasma and its high state of preservation indicate the important role of this protein in mammalian. In addition, β2GPI has a particular structure in the fifth domain, and is categorized as the major antigen recognized by autoa...

نشانگان آنتی فسفولیپید

Antiphospholipid syndrome is an autoimmune condition characterized by recurrent vascular thrombosis, pregnancy loss and thrombocytopenia associated with moderate to high levels of antiphospholipid antibodies. Most of clinical features are results of thrombotic phenomena. The pathophysiologic basis ot this syndrome is still unknown. the diagnosis of this syndrome is made by combination of clinic...

Antiphospholipid Syndrome Presenting with Superior Vena Cava Thrombosis

Oral contraceptive-related transverse sinus thrombosis as an initial manifestation of antiphospholipid syndrome in the absence of systemic lupus erythematosus

The Flare Up of Catastrophic Antiphospholipid Syndrome: a Report of an Immunosuppressive Withdrawal-Induced Case

Antiphospholipid syndrome (APS) is a systemic disease that causes venous and arterial thrombosis in virtually any organ. Sometimes it is complicated into pulmonary infarction and cavitation, pulmonary hypertension, and catastrophic course with high morbidity and mortality. The present case is a 35-year-old woman with one episode of postpartum deep veins throm-bosis (DVT) 12 years earlier and th...